CLA and Creatine Combination Good for Increasing Muscle Mass and Losing Fat
            Renowned muscle physiologist Mark Tarnopolsky wrote an excellent review article this month in the Journal of Applied Physiology Nutrition and Metabolism on the benefits of creatine and CLA for increasing muscle mass and losing bodyfat.  CLA has been shown to reduce body fat as well as increase lean muscle mass.  CLA has also been found to increase IGF-1 and enhance IGF-1 binding proteins which can contribute to its marked anabolic effects on muscle.  CLA also has potent anti-inflammatory effects which reduces chronic inflammation which can suppress muscle hypertrophy.  CLA is especially good at suppressing Interleukin-6 which is catabolic cytokine and reduces muscle mass.  The review article highlighted a recent study which showed the combination of creatine and CLA resulted in greater fat loss than creatine alone.  The review article suggests that older men and women are likely to see enhanced benefit from CLA supplementation-- increased lean muscle mass and reduced stored body-fat.   

CLA inhibits Fat Loss thru Delta 6-Desaturase
Americans have drastically reduced their consumption of the most prevalent sources of CAL (beef, whole milk, eggs, and cheese) to reduce overall fat and cholesterol. Lite and low-fat versions of dairy products are mostly devoid of CLA. Another factor reducing how much CLA we eat today is that cows make CLA from linoleic acid, which is found in grasses but occurs in low levels in the type of mixed grain feed now used by most cattle farmers. Other sources of CLA include turkey, chicken, and vegetable oils.  To get the most beneficial effects of CLA, supplementation is warranted.  Delta 6-Desaturase is the rate-limiting enzyme for converting alpha linolenic acid (an essential fatty acid) into longer essential fatty acid metabolites, (eicosapentaenoic acid and gamma linolenic acid). Delta 6-Desaturase decreases with age, magnesium deficiency, and also is inhibited by Trans Fatty Acids.  In the journal of Obesity, mice were fed diets with or without CLA and inhibitors of Δ6-desaturase.  CLA caused a loss of body fat and depressed the individual fat pad weights and total body fat percent compared to the control group. The body fat loss was blocked by the Δ6-desaturase inhibitor. The researchers concluded that Inhibition of Δ6-desaturase prevented CLA from being able to cause a body fat loss. Therefore, a desaturated metabolite of CLA appears to be involved in the CLA antiobesity effect.  Since Delta 6-Desaturase decreases with age, using a high quality supplement like Omegalyze with CLA, and a healthy balance on Omega-3 and 6’s could reduce age related increases in bodyfat.

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