SOMALYZEGEN2 is a non-stimulant based fat burner that, simultaneously, functions as a sleep aid. The following paragraphs describe the unique blend of ingredients in SOMALYZE and the complex mechanisms of how they function to metabolize fat while you sleep.
Oleoylethanolamide (OEA)
OEA is is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-á) agonist synthesized in the intestines. PPAR-á is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids).
OEA has also been shown to have anorexic properties, meaning it decreases food intake and sends hunger-curbing messages to the brain.
If all that weren't enough, OEA can also lower lower blood cholesterol and triglyceride levels.
PROPIONYL L-CARNITINE:
Inside the cell, L-carnitine transports long chain fats into the mitochondria (energy-producing chamber) where they are then oxidized into ATP. In theory, if we can increase the amount of L-carnitine within the muscle, we can theoretically increase the quantity of fatty acids that get oxidized. Until recently the problem has been that regular L-carnitine and even the more exotic acetyl-L-carnitine lacked the ability to penetrate skeletal muscle tissue (which is where most fat oxidation occurs).
On the other hand, Propionyl-L-carnitine, a relatively new version of L-carnitine, has important effects on skeletal and cardiac muscle. Back in 1990, a human study demonstrated that propionyl-L-carnitine could combat the destructive effects of low oxygen status and muscle fatigue in heart and skeletal muscle. More relevant to our discussion is the fact that propionyl-L-carnitine has a tremendous ability to penetrate skeletal muscle and thus facilitate the transport of long chain fatty acids into the mitochondria.
GAMMA AMINOBUTYRIC ACID
GABA (Gamma Aminobutyric Acid) is an amino acid-derived neurotransmitter - a chemical that transmits messages between nerve cells - that's found predominantly in the hypothalamus of the brain. This is an important fact since the hypothalamus is located in a region of the brain (posterior lobe) that's responsible for visceral functions such as sleep cycles, body temperature and the activity of the pituitary gland.
The pituitary gland is the master endocrine gland affecting all hormonal functions of the body. Numerous studies have shown that as GABA levels increase in this posterior region of the brain, plasma growth hormone (GH) levels also increase. This is significant for the athlete since GH dramatically mobilizes fat and rebuilds damaged muscle tissue.
GABA also has a slight relaxing or sedative effect on the body which makes it ideal for use at bedtime. Many people report improved sleep patterns and a well rested feeling upon arising. Colorful and somewhat lucid dreams are also frequently reported. Remember, as your quality of sleep increases, your ability to recover from stress and strenuous exercise also increases. Recent research has also demonstrated that well-rested individuals have much higher levels of appetite-suppressing leptins in the body the more you sleep, the less you'll feel like eating.
Aside from the positive effects of burning stored body fat and getting a restful night sleep, individuals may experience some of GABAs other unique qualities. Some people report a skin surface tingling sensation for a few minutes after taking GABA. This is not uncommon and can be likened to a niacin "flush". Some also report a slight shortness of breath for a few minutes after taking GABA. This also is not uncommon and is nothing that is of serious concern.
MELATONIN
The pineal gland (located in the brain) synthesizes and secretes the hormone, melatonin a structurally simple hormone that communicates information about environmental lighting to various parts of the body and then establishes specific circadian rhythms that inform the body whether it is day or night. This light-transducing ability of the pineal gland has led some to call the pineal gland the third eye.
Normally in the body, the timing of melatonin secretion is controlled by neural pathways that run from the retina of the eye to the hypothalamus and from the hypothalamus to the pineal gland. Interestingly, it's the suprachiasmatic nucleus of the hypothalamus that controls bodily circadian cycles such as core body temperature, cortisol secretion, sleepiness, and melatonin secretion.
Melatonin preserves mitochondrial homeostasis, reduces free radical generation and maintains ATP synthesis by stimulating electron flow through complex I and IV of the electron transport chain, even in the presence of uncoupling agents such as Usnic Acid and DNP.
When taken in supplement form, melatonin appears to be remarkably safe. Because of this fact, it's been used for years in the treatment of certain sleep and mood disorders. One rather common condition that involves the disruption of natural circadian rhythms is "jet lag". When traveling across time zones, it's been repeatedly demonstrated that ingestion of melatonin close to the target bedtime of the visited location significantly alleviates most symptoms of "jet lag".
Once again, a restful night sleep significantly increases the body's ability to repair itself and more sleep translates to less hunger. Finally, don't be surprised if you experience vivid, colorful, dreams while taking SOMALYZE.
PHOSPHATIDYLCHOLINE (PC) and PHOSPHATIDYLETHANOLAMINE (PE)
Phosphatidylcholine and Phosphatidylethanolamine have been shown to reduce elevations of stress hormones such as ACTH and cortisol that are associated with strenuous exercise. This is an extremely important finding, since age-related increases in the cortisol/DHEA ratio are a significant biomarker of aging. This changing ratio increased cortisol and decreased DHEA reflects the toxic effects on the body to prolonged increases in cortisol levels (hypercortisolemia). These effects can ultimately manifest as the "Cushingoid" appearance (bloated face, fat stomach, and soft look) of many people over the age of 50. Consequently, many studies have demonstrated that the cortisol-blocking effects of phosphatidylcholine and phosphatidylethanolamine may profoundly delay these adverse effects of aging.
Remember, whenever we exercise, the trauma of the workout creates stress in the body. In response, the adrenal glands release tons of the stress hormone, cortisol. Cortisol is a catabolic hormone that breaks down muscle, suppresses the immune system and precipitates the storage of ugly abdominal fat. Phosphatidylcholine and phosphatidylethanolamine can blunt this cortisol releasing effect to exercise and thus greatly enhance the body's ability to repair itself and to suppress the accumulation of annoying body fat.
LIPOLYZE e2
Non-stimulant Fat Burner
LIPOLYZEÂ e2Â can be best categorized as a caloric wasting compound. Whereas most fat burning formulations on today's market depend on stimulants such as ephedra (rarely seen today), caffeine, PEA, synephrine, and other CNS agonists; at SPECIES we reject the premise that the only effective way to burn fat is to "stimulate" the body into submission. While stimulants do increase metabolic rate, they also increase the production of catabolic (muscle wasting) hormones such as cortisol. As cortisol levels rise in the body, lean muscle tissue is broken down, immune system function is suppressed and dangerous abdominal belly fat deposition is increased.Â
Remember, the quantity of lean muscle in the body is highly correlated with the basal metabolic rate (BMR). Less muscle means a lower BMR! If stimulant-based fat burners are used to help shed unwanted body fat, there's a very good chance that, once they’re discontinued, metabolic rate will be significantly lower and the predisposition to gain unwanted body fat will be significantly higher.Â
If this scenario wasn't bad enough, stimulants raise blood pressure, increase heart rate, and increase anxiety levels. Therefore, individuals with a history of heart disease, high blood pressure, or brain chemistry abnormalities should certainly steer clear of these compounds.
The following paragraphs explain the various compounds found in the all-new LIPOLYZE-e2 formula.
APPETITTE SUPPRESSION TECHNOLOGY
(a)Â IRVINGIA GABONESIS (African Mango)
Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in these fat cells.  Overweight individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from overeating.
An extract from African mango called Irvingia gabonensis has been shown to help support leptin sensitivity in overweight people.  In addition to supporting healthy leptin sensitivity, irvingia has demonstrated the following beneficial effects on key aspects of metabolism:
Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat. Irvingia has been shown to reduce the activity of glycerol-3-phosphate dehydrogenase which may reduce the amount of carbs stored as fat.
Irvingia has alpha-amylase-inhibiting properties5Â which can help support a slowing of the rate of carbohydrate absorption from the intestines and thus a decrease in rate at which the fat-storing hormone, insulin, is released.
Adiponectin is a hormone involved in helping to maintain insulin sensitivity.  Better insulin sensitivity means less fat storage. Scientific data suggests that irvingia helps support healthy adiponectin levels.
 (b)  OLEOYLETHANOLAMIDE  (OEA)
OEA is is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-á) agonist synthesized in the intestines. PPAR-á is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (storage of fatty acids).
OEA has also been shown to have anorexic properties, meaning it decreases food intake and sends hunger-curbing messages to the brain.
If all that weren't enough, OEA can also lower lower blood cholesterol and triglyceride levels.
MITOCHONDRIAL OPTIMIZATION & REGENERATION
NEW RESEARCH shows that the combination of ACETYL L-CARNITINE and R-LIPOIC ACID will regenerate new mitochondria, stabilize the membranes of existing mitochondria, and prevent oxidative damage from free radicals. More stable, more efficient, more prolific mitochondria will oxidize fats more efficiently which ultimately will lead to greater fat loss.Â
Likewise, healthier mitochondria slow the aging process of cells meaning that the 1-2 punch of Acetyl L-Carnitine and R-Lipoic Acid can have anti-aging effects on the cells of the body.  Just imagine, you can burn unwanted bodyfat while, simultaneously, increasing the lifespan of your cells.
ALPHA LIPOIC ACID(ALA)
(c)Â Â ACETYL L-CARNITINE
Inside the cell, L-carnitine transports long chain fats into the mitochondria (energy-producing chamber) where they are then oxidized into ATP. In theory, if we can increase the amount of L-carnitine within the muscle, we can theoretically increase the quantity of fatty acids that get oxidized. Until recently the problem has been that regular L-carnitine lacked the ability to penetrate skeletal muscle tissue (which is where most fat oxidation occurs). The fat soluble forms of L-carnitine—acetyl l-carnitine and propionyl l-carnitine-- greatly increase absorbability and penetration into skeletal muscle and thus facilitate the transport of long chain fatty acids into the mitochondria.
 (d)   VITAMIN E
Whenever fatty acid oxidation is increased, there’s a concomitant increase in dangerous free radicals.  Vitamin E acts as an antioxidant and neutralizes these dangerous rogue electrons.Â
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THYROID SUPPORT
(e)Â Â GUGGULSTERONES Z & E
The thyroid gland releases a hormone known commonly as thyroxin (T4 for short). T4 is an inactive form of thyroid hormone that must ultimately be converted into triiodothyronine (T3), the active thyroid hormone. Whenever any sort of diet is initiated, the body's natural inclination is to slow down the conversion of T4 (inactive) to T3 (active). Ultimately, when this happens, metabolic rate slows and fat losses crawl to a halt.Â
In India, the Guggul is a tree which exudes a resinous sap out of incisions that are made in its bark. This resin has been used for centuries as part of Indias traditional medicine called Ayurveda. This resinous sap can be processed, purified, and then standardized for its active components Guggulsterones Z and Guggulsterones E. These two fractionations have the unique ability to support thyroid function by increasing the conversion of inactive T4 into active T3 and, in doing so, restore normal thyroid function to the dieting athlete.
 FAT MOBILIZATION MATRIX
(f)Â Â Â GREEN TEA EXTRACT
Green Tea Extract (Camellia sinesis leaf) is a powerful antioxidant similar to vitamin C, vitamin E, and beta-carotene. However, researchers have suggested that the active ingredient called epigallocatechin gallate (EGCG) may, amazingly, have 200 times the antioxidant properties of vitamin E. A study from the American Journal of Clinical Nutrition revealed that green tea extract caused a significant increase in energy expenditure and fatty acid oxidation. The researchers noted a 4% increase in 24-hour energy expenditure which actually translates to a 35-43% increase in daytime thermogenesis. What's even more significant to cardiac and thyroid patients is the fact that none of the research subjects reported any of the side effects rapid heart rate, elevated blood pressure, or increased anxiety that are commonly seen with the multitude of stimulant-based fat burners.
